Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.

Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.

Traditionally, non-small cell lung cancer is treated as a single disease entity in terms of systemic therapy. Emerging evidence suggests the major subtypes--adenocarcinoma (AC) and squamous cell carcinoma (SqCC)--respond differently to therapy. Identification of the molecular differences between the...

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Main Authors: William W Lockwood, Raj Chari, Bradley P Coe, Kelsie L Thu, Cathie Garnis, Chad A Malloff, Jennifer Campbell, Ariane C Williams, Dorothy Hwang, Chang-Qi Zhu, Timon P H Buys, John Yee, John C English, Calum Macaulay, Ming-Sound Tsao, Adi F Gazdar, John D Minna, Stephen Lam, Wan L Lam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC2910599?pdf=render

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