Inhibition of EGFR signaling: all mutations are not created equal.

by Adi F Gazdar, John D Minna
Published 2005-11-01

TP53 Abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma§

by Mauricio Moreno, Fernando Pimentel, Adi F. Gazdar, Ignacio I. Wistuba, Juan F. Miquel
Published 2005-07-01

Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures

by Luka Brcic, Christian Kuchler, Sylvia Eidenhammer, Daniela Pabst, Franz Quehenberger, Adi F. Gazdar, Helmut Popper
Published 2019-05-01

ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration

by Jia-Hao Bi, Yi-Fan Tong, Zhe-Wei Qiu, Xing-Feng Yang, John Minna, Adi F. Gazdar, Kai Song
Published 2019-06-01

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas

by Yu-An Zhang, Yunyun Zhou, Xin Luo, Kai Song, Xiaotu Ma, Adwait Sathe, Luc Girard, Guanghua Xiao, Adi F Gazdar
Published 2016-11-01

Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer.

by Bradley P Coe, Kelsie L Thu, Sarit Aviel-Ronen, Emily A Vucic, Adi F Gazdar, Stephen Lam, Ming-Sound Tsao, Wan L Lam
Published 2013-01-01

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

by Min He, Shanshan Liu, Sachith Gallolu Kankanamalage, Mark D. Borromeo, Luc Girard, Adi F. Gazdar, John D. Minna, Jane E. Johnson, Melanie H. Cobb
Published 2018-04-01

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

by Mark D. Borromeo, Trisha K. Savage, Rahul K. Kollipara, Min He, Alexander Augustyn, Jihan K. Osborne, Luc Girard, John D. Minna, Adi F. Gazdar, Melanie H. Cobb, Jane E. Johnson
Published 2016-08-01

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

by Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F Gazdar, John D Minna, Jonathan R Pollack
Published 2009-07-01

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

by Jeet Gandhi, Jianling Zhang, Yang Xie, Junichi Soh, Hisayuki Shigematsu, Wei Zhang, Hiromasa Yamamoto, Michael Peyton, Luc Girard, William W Lockwood, Wan L Lam, Marileila Varella-Garcia, John D Minna, Adi F Gazdar
Published 2009-01-01

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

by Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar, Michael G. Roth
Published 2017-01-01

Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.

by Kelsie L Thu, Emily A Vucic, Raj Chari, Wei Zhang, William W Lockwood, John C English, Rong Fu, Pei Wang, Ziding Feng, Calum E MacAulay, Adi F Gazdar, Stephen Lam, Wan L Lam
Published 2012-01-01

Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.

by Masaharu Nomura, Hisayuki Shigematsu, Lin Li, Makoto Suzuki, Takao Takahashi, Pila Estess, Mark Siegelman, Ziding Feng, Harubumi Kato, Antonio Marchetti, Jerry W Shay, Margaret R Spitz, Ignacio I Wistuba, John D Minna, Adi F Gazdar
Published 2007-04-01

miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.

by Liqin Du, Maria C Subauste, Christopher DeSevo, Zhenze Zhao, Michael Baker, Robert Borkowski, Jeoffrey J Schageman, Rachel Greer, Chin-Rang Yang, Milind Suraokar, Ignacio I Wistuba, Adi F Gazdar, John D Minna, Alexander Pertsemlidis
Published 2012-01-01

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.

by Junichi Soh, Naoki Okumura, William W Lockwood, Hiromasa Yamamoto, Hisayuki Shigematsu, Wei Zhang, Raj Chari, David S Shames, Ximing Tang, Calum MacAulay, Marileila Varella-Garcia, Tõnu Vooder, Ignacio I Wistuba, Stephen Lam, Rolf Brekken, Shinichi Toyooka, John D Minna, Wan L Lam, Adi F Gazdar
Published 2009-10-01

Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor.

by Hans K Ghayee, Vikash J Bhagwandin, Victor Stastny, Arielle Click, Liang-Hao Ding, Dario Mizrachi, Ying S Zou, Raj Chari, Wan L Lam, Robert M Bachoo, Alice L Smith, Michael D Story, Stan Sidhu, Bruce G Robinson, Fiemu E Nwariaku, Adi F Gazdar, Richard J Auchus, Jerry W Shay
Published 2013-01-01

Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.

by William W Lockwood, Raj Chari, Bradley P Coe, Kelsie L Thu, Cathie Garnis, Chad A Malloff, Jennifer Campbell, Ariane C Williams, Dorothy Hwang, Chang-Qi Zhu, Timon P H Buys, John Yee, John C English, Calum Macaulay, Ming-Sound Tsao, Adi F Gazdar, John D Minna, Stephen Lam, Wan L Lam
Published 2010-07-01

A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.

by David S Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna
Published 2006-12-01

Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.

by William W Lockwood, Ian M Wilson, Bradley P Coe, Raj Chari, Larissa A Pikor, Kelsie L Thu, Luisa M Solis, Maria I Nunez, Carmen Behrens, John Yee, John English, Nevin Murray, Ming-Sound Tsao, John D Minna, Adi F Gazdar, Ignacio I Wistuba, Calum E MacAulay, Stephen Lam, Wan L Lam
Published 2012-01-01

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

by Ling Cai, Hongyu Liu, Fang Huang, Junya Fujimoto, Luc Girard, Jun Chen, Yongwen Li, Yu-An Zhang, Dhruba Deb, Victor Stastny, Karine Pozo, Christin S. Kuo, Gaoxiang Jia, Chendong Yang, Wei Zou, Adeeb Alomar, Kenneth Huffman, Mahboubeh Papari-Zareei, Lin Yang, Benjamin Drapkin, Esra A. Akbay, David S. Shames, Ignacio I. Wistuba, Tao Wang, Jane E. Johnson, Guanghua Xiao, Ralph J. DeBerardinis, John D. Minna, Yang Xie, Adi F. Gazdar
Published 2021-03-01