Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Amyloid-Related Memory Decline in Preclinical Alzheimer's Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and cognitive decline is unclear. The aim of this study was to investigate the r...

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Bibliographic Details
Main Authors: Christine Thai, Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Kathryn A Ellis, Stephanie R Rainey-Smith, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruff, Australian Imaging, Biomarkers and Lifestyle (AIBL) Research Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4592244?pdf=render

Internet

http://europepmc.org/articles/PMC4592244?pdf=render

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