RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells

RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells

POLR3G is expressed at high levels in human pluripotent stem cells (hPSCs) and is required for maintenance of stem cell state through mechanisms not known in detail. To explore how POLR3G regulates stem cell state, we carried out deep-sequencing analysis of polyA+ and smallRNA transcriptomes present...

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Bibliographic Details
Main Authors: Riikka J. Lund, Nelly Rahkonen, Maia Malonzo, Leni Kauko, Maheswara Reddy Emani, Virpi Kivinen, Elisa Närvä, Esko Kemppainen, Asta Laiho, Heli Skottman, Outi Hovatta, Omid Rasool, Matti Nykter, Harri Lähdesmäki, Riitta Lahesmaa
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Stem Cell Reports
Subjects:
pluripotency
human embryonic stem cell
polymerase III
transcriptome
smallRNA
polyA+ RNA
splicing
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301704

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http://www.sciencedirect.com/science/article/pii/S2213671117301704

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