Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2

Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2

As a physiological small molecular product from the microbial fermentation of dietary fibers, butyrate plays an important role in maintaining intestinal health. Our previous works have proved that the effect of sodium butyrate (NaB) on the intestinal barrier function is mediated by activation of AMP...

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Bibliographic Details
Main Authors: Wei Miao, Xiujuan Wu, Kang Wang, Wenjing Wang, Yumei Wang, Zhigang Li, Jingjing Liu, Li Li, Luying Peng
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Molecular Sciences
Subjects:
butyrate
tight junction
Caco-2
myosin light chain kinase (MLCK)
myosin II regulatory light chain (MLC2)
(protein kinase C β) PKCβ
Online Access:http://www.mdpi.com/1422-0067/17/10/1696

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http://www.mdpi.com/1422-0067/17/10/1696

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