Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis

Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis

Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell survival.

Bibliographic Details
Main Authors: Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01850-4

Internet

https://doi.org/10.1038/s41467-017-01850-4

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