Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

Abstract Background The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets for therapeutic developments. In a relatively limited subset of NSCLC,...

Full description

Bibliographic Details
Main Authors: I-Chun Lai, Gi-Ming Lai, Jyh-Ming Chow, Hsin-Lun Lee, Chuan-Feng Yeh, Chi-Han Li, Jiann-Long Yan, Shuang-En Chuang, Jacqueline Whang-Peng, Kuan-Jen Bai, Chih-Jung Yao
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Chinese Medicine
Subjects:
Non-small cell lung cancer
HS7
Taiwanofungus camphoratus
AKT-mTOR
ERK
STAT3
Online Access:http://link.springer.com/article/10.1186/s13020-017-0154-9

Internet

http://link.springer.com/article/10.1186/s13020-017-0154-9

Similar Items