Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species

The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles. The objective of this stud...

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Bibliographic Details
Main Authors: Danielly Beraldo dos Santos Silva, Luana Mireli Carbonera Rodrigues, Adriana Araújo de Almeida, Kelly Mari Pires de Oliveira, Alexéia Barufatti Grisolia/
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2016-03-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
yeasts
Candida krusei
voriconazole
14α-demethylase
Y166S
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300192&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300192&lng=en&tlng=en

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