Cold Tumors: A Therapeutic Challenge for Immunotherapy

Cold Tumors: A Therapeutic Challenge for Immunotherapy

Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains relatively low in most cases. A major factor involved in initial resistance to ICP inhibitors is the lack or paucity of tumor T cell infiltration,...

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Bibliographic Details
Main Authors: Paola Bonaventura, Tala Shekarian, Vincent Alcazer, Jenny Valladeau-Guilemond, Sandrine Valsesia-Wittmann, Sebastian Amigorena, Christophe Caux, Stéphane Depil
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
cold tumors
T cells
tumor antigen
presentation
priming
trafficking
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00168/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00168/full

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