Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling

Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling

The greatest challenge in cancer therapy is posed by drug-resistant recurrence following treatment. Anticancer chemotherapy is largely focused on targeting the rapid proliferation and biosynthesis of cancer cells. This strategy has the potential to trigger autophagy, enabling cancer cell survival th...

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Bibliographic Details
Main Authors: Jae-Seon Lee, Ho Lee, Hyonchol Jang, Sang Myung Woo, Jong Bae Park, Seon-Hyeong Lee, Joon Hee Kang, Hee Yeon Kim, Jaewhan Song, Soo-Youl Kim
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
cancer metabolism
energy metabolism
aldehyde dehydrogenase
oxidative phosphorylation (OxPhos), ATP production
Online Access:https://www.mdpi.com/2073-4409/9/9/2013

Internet

https://www.mdpi.com/2073-4409/9/9/2013

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