The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer.

The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer.

Proliferation, either as the main common denominator in genetic profiles, or in the form of single factors such as Ki67, is recommended for clinical use especially in estrogen receptor-positive (ER) patients. However, due to high costs of genetic profiles and lack of reproducibility for Ki67, studie...

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Main Authors: Marie Klintman, Carina Strand, Cecilia Ahlin, Sanda Beglerbegovic, Marie-Louise Fjällskog, Dorthe Grabau, Einar Gudlaugsson, Emiel A M Janssen, Kristina Lövgren, Ivar Skaland, Pär-Ola Bendahl, Per Malmström, Jan P A Baak, Mårten Fernö
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3852976?pdf=render

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http://europepmc.org/articles/PMC3852976?pdf=render

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