Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regulate inflammatory gene transcription. We show that...

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Bibliographic Details
Main Authors: Sylwia Wasiak, Dean Gilham, Emily Daze, Laura M. Tsujikawa, Christopher Halliday, Stephanie C. Stotz, Brooke D. Rakai, Li Fu, Ravi Jahagirdar, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski
Format: Article
Language:English
Published: Hindawi-Wiley 2020-01-01
Series:Cardiovascular Therapeutics
Online Access:http://dx.doi.org/10.1155/2020/9397109

Internet

http://dx.doi.org/10.1155/2020/9397109

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