Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD Mice

Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD Mice

Insulin is a key autoantigen in Type 1 Diabetes (T1D), targeted by both T and B cells. Therefore, understanding insulin-specific T:B cell interactions is important. We have previously reported an insulin-reactive CD4+ T cell, (designated 2H6). Unlike other insulin-reactive T cells, 2H6 cells protect...

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Bibliographic Details
Main Authors: James A. Pearson, Yangyang Li, Monika Majewska-Szczepanik, Junhua Guo, Li Zhang, Yu Liu, F. Susan Wong, Li Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
insulin
Type 1 diabetes
B cells
T cells
TGFβ
germinal center
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.585886/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.585886/full

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