Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment

Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment

The hepatitis C virus (HCV) RNA replication cycle is a dynamic intracellular process occurring in three-dimensional space (3D), which is difficult both to capture experimentally and to visualize conceptually. HCV-generated replication factories are housed within virus-induced intracellular structure...

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Bibliographic Details
Main Authors: Markus M. Knodel, Paul Targett-Adams, Alfio Grillo, Eva Herrmann, Gabriel Wittum
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Environmental Research and Public Health
Subjects:
computational virology
hepatitis C virus (HCV)
viral dynamics
within-host viral modeling
mathematical models of viral RNA cycle
population dynamics
3D spatiotemporal resolved mathematical models
realistic geometries
(surface) partial differential equations
Finite Volumes
massively parallel multigrid solvers
Online Access:https://www.mdpi.com/1660-4601/16/3/513

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https://www.mdpi.com/1660-4601/16/3/513

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