SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

The establishment and maintenance of pluripotency depend on precise coordination of gene expression. We establish serine-arginine-rich splicing factor 3 (SRSF3) as an essential regulator of RNAs encoding key components of the mouse pluripotency circuitry, SRSF3 ablation resulting in the loss of plur...

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Bibliographic Details
Main Authors: Madara Ratnadiwakara, Stuart K Archer, Craig I Dent, Igor Ruiz De Los Mozos, Traude H Beilharz, Anja S Knaupp, Christian M Nefzger, Jose M Polo, Minna-Liisa Anko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
SR protein
RNA processing
pluripotent
reprogramming
mRNA export
alternative splicing
Online Access:https://elifesciences.org/articles/37419

Internet

https://elifesciences.org/articles/37419

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