Reduced HDAC2 in skeletal muscle of COPD patients

Reduced HDAC2 in skeletal muscle of COPD patients

Abstract Background Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The aim of this study was to investigate the role of histone deacetylases(...

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Bibliographic Details
Main Authors: Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito, Peter J. Barnes
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
COPD
Skeletal muscle dysfunction
HDAC2
Nuclear factor-kappa B
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12931-017-0588-8

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http://link.springer.com/article/10.1186/s12931-017-0588-8

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