Activation of Toll-like Receptor-2 by Endogenous Matrix Metalloproteinase-2 Modulates Dendritic-Cell-Mediated Inflammatory Responses

Activation of Toll-like Receptor-2 by Endogenous Matrix Metalloproteinase-2 Modulates Dendritic-Cell-Mediated Inflammatory Responses

Summary: Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism unde...

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Bibliographic Details
Main Authors: Emmanuelle Godefroy, Anne Gallois, Juliana Idoyaga, Miriam Merad, Navpreet Tung, Ngozi Monu, Yvonne Saenger, Yichun Fu, Rajesh Ravindran, Bali Pulendran, Francine Jotereau, Sergio Trombetta, Nina Bhardwaj
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400936X

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http://www.sciencedirect.com/science/article/pii/S221112471400936X

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