CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response

CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response

Background: Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids (AA) to form epoxyeicosatrienoic acids (EETs), which exert beneficial roles in the treatment of cardiovascular diseases, but little is known about its role on adventitial remodeling. Methods: We used C57BL/6J mice in vivo an...

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Bibliographic Details
Main Authors: Chi Zhou, Jin Huang, Junxiong Chen, Jinsheng Lai, Fasheng Zhu, Xizhen Xu, Dao Wen Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Adventitial remodeling
Cytochrome P450 epoxygenase 2J2
Epoxyeicosatrienoic acids
Angiotensin II
PPARγ
Online Access:http://prod.karger.com/Article/FullText/445663

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http://prod.karger.com/Article/FullText/445663

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