Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice

Oxidative stress is believed to greatly contribute to the pathogenesis of various diseases, including neurodegeneration. Impairment of mitochondrial energy production and increased mitochondrial oxidative damage are considered early pathological events that lead to neurodegeneration. Manganese sup...

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Bibliographic Details
Main Authors: Naotaka Izuo, Hidetoshi Nojiri, Satoshi Uchiyama, Yoshihiro Noda, Satoru Kawakami, Shuji Kojima, Toru Sasaki, Takuji Shirasawa, Takahiko Shimizu
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2015/238914