A simple microscopy setup for visualizing cellular responses to DNA damage at particle accelerator facilities

Abstract Cellular responses to DNA double-strand breaks (DSBs) not only promote genomic integrity in healthy tissues, but also largely determine the efficacy of many DNA-damaging cancer treatments, including X-ray and particle therapies. A growing body of evidence suggests that activation of the mec...

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Bibliographic Details
Main Authors: Haibin Qian, Ron A. Hoebe, Michel R. Faas, Marc Jan van Goethem, Emiel R. van der Graaf, Christoph Meyer, Harry Kiewiet, Sytze Brandenburg, Przemek M. Krawczyk
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92950-1