Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing

Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing

Abstract Background Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CGRP in an animal model that mimics the chronic migraine condition via re...

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Bibliographic Details
Main Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Cristina Tassorelli
Format: Article
Language:English
Published: BMC 2018-07-01
Series:The Journal of Headache and Pain
Subjects:
Nitroglycerin
Topiramate
CGRP
Trigeminal nociception
Online Access:http://link.springer.com/article/10.1186/s10194-018-0879-6

Internet

http://link.springer.com/article/10.1186/s10194-018-0879-6

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