The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes

The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes

D609 is known to modulate death receptor-induced ceramide generation and cell death. We show that in Jurkat cells, non-toxic D609 concentrations inhibit sphingomyelin synthase and, to a lesser extent, glucosylceramide synthase, and transiently increase the intracellular ceramide level. D609 signific...

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Bibliographic Details
Main Authors: Bruno Ségui, Thierry Levade, Hervé Benoist, Delphine Milhas, Nathalie Andrieu-Abadie
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:International Journal of Molecular Sciences
Subjects:
CD95
apoptosis
necrosis
sphingomyelin synthase
glucosylceramide synthase
ALPS
Online Access:http://www.mdpi.com/1422-0067/13/7/8834

Internet

http://www.mdpi.com/1422-0067/13/7/8834

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