A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation

A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation

Abstract Enteric glial cells (EGC) modulate motility, maintain gut homeostasis, and contribute to neuroinflammation in intestinal diseases and motility disorders. Damage induces a reactive glial phenotype known as “gliosis”, but the molecular identity of the inducing mechanism and triggers of “enter...

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Bibliographic Details
Main Authors: Reiner Schneider, Patrick Leven, Tim Glowka, Ivan Kuzmanov, Mariola Lysson, Bianca Schneiker, Anna Miesen, Younis Baqi, Claudia Spanier, Iveta Grants, Elvio Mazzotta, Egina Villalobos‐Hernandez, Jörg C Kalff, Christa E Müller, Fedias L Christofi, Sven Wehner
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:EMBO Molecular Medicine
Subjects:
enteric nervous system
gut inflammation
motility disorders
postoperative ileus
purinergic signaling
Online Access:https://doi.org/10.15252/emmm.202012724

Internet

https://doi.org/10.15252/emmm.202012724

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