Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells

Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells

Hypoxia-inducible factor 1 (HIF-1) plays important roles in cancer cell biology. HIF-1α is reportedly activated by several factors, including protein kinase C (PKC), in addition to hypoxia. We investigated the role of PKC isoforms and the effects of vitamin K2 (VK2) in the activation proces...

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Bibliographic Details
Main Authors: Jinghe Xia, Iwata Ozaki, Sachiko Matsuhashi, Takuya Kuwashiro, Hirokazu Takahashi, Keizo Anzai, Toshihiko Mizuta
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
Vitamin K2
Hypoxia-inducible factor-1α (HIF-1α)
Protein kinase C (PKC)
Hepatocellular carcinoma cells
Online Access:https://www.mdpi.com/1422-0067/20/5/1022

Internet

https://www.mdpi.com/1422-0067/20/5/1022

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