Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

Abstract Background Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibitors of DNA-Damage Response (DDR) on tumor cell radiosensitivity under...

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Bibliographic Details
Main Authors: Carmen Klein, Ivana Dokic, Andrea Mairani, Stewart Mein, Stephan Brons, Peter Häring, Thomas Haberer, Oliver Jäkel, Astrid Zimmermann, Frank Zenke, Andree Blaukat, Jürgen Debus, Amir Abdollahi
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Radiation Oncology
Subjects:
Hypoxia
Lung cancer
Radioresistance
DNA-Pk
ATM
Serine/threonine kinase inhibitors
Online Access:http://link.springer.com/article/10.1186/s13014-017-0939-0

Internet

http://link.springer.com/article/10.1186/s13014-017-0939-0

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