Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels

Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels

Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer progression through numerous cancer cell non-autonomous mechanisms, including...

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Bibliographic Details
Main Authors: Andrés Tittarelli, Mariela Navarrete, Marcelo Lizana, Francisca Hofmann-Vega, Flavio Salazar-Onfray
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
connexin-43
map junctions
microRNAs
melanoma
hypoxia
cytotoxic T lymphocytes
Online Access:https://www.mdpi.com/1422-0067/21/20/7567

Internet

https://www.mdpi.com/1422-0067/21/20/7567

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