GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis

GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis

Abstract Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation. Colorectal cancer is often accompanied with chronic inflammation. Differed from its well-known oncogenic role in many malignancies, we present here that Golgi membrane pr...

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Bibliographic Details
Main Authors: Yang Pu, Ya Song, Mengdi Zhang, Caifeng Long, Jie Li, Yanan Wang, Yinzhe Xu, Fei Pan, Na Zhao, Xinyu Zhang, Yanan Xu, Jianxin Cui, Hongying Wang, Yan Li, Yong Zhao, Di Jin, Hongbing Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00535-1

Internet

https://doi.org/10.1038/s41392-021-00535-1

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