A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

We previously synthesized an hydroxamate derivative (N-hydroxy-4-[2-(3- methoxyphenyl)acetamido]benzamide) named 363 with potent anti-<i>Toxoplasma gondii</i> activity and histone deacetylase inhibitor (HDACi) effects. Here we show that 1-N-hydroxy-4-N- [(2-methoxyphenyl)methyl]benzene-1...

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Bibliographic Details
Main Authors: Corinne Loeuillet, Bastien Touquet, Jean François Guichou, Gilles Labesse, Denis Sereno
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/12/2973