TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells

TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells

Abstract Background Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invasion have not been fully established. Methods To specifically test the i...

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Bibliographic Details
Main Authors: Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle, Claire M. Wells
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Pancreatic ductal adenocarcinoma
Monocytes
Tumor microenvironment
TIMP2
Invadopodia
Online Access:https://doi.org/10.1186/s12885-019-6429-z

Internet

https://doi.org/10.1186/s12885-019-6429-z

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