TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells
Abstract Background Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invasion have not been fully established. Methods To specifically test the i...
Main Authors: | Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle, Claire M. Wells |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
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Series: | BMC Cancer |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12885-019-6429-z |
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