Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids.

Incubation of the four purified HMG-CoA reductase phosphatases with the sodium salts of eleven polycarboxylic acids at concentrations of 40 mM, inactivated the enzymes to different degrees depending on the structure of the carboxylic acids. Maleate, malonate, oxalate, citrate, and hydroxymethylgluta...

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Bibliographic Details
Main Authors: F G Hegardt, G Gil, V E Calvet
Format: Article
Language:English
Published: Elsevier 1983-07-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752037927X