Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to humans. This success has motivated research to identif...

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Bibliographic Details
Main Authors: Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
drug delivery
hepatocyte
lipid nanoparticles
polyethylene glycol
siRNA
prenatal diagnosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301974

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http://www.sciencedirect.com/science/article/pii/S2162253116301974

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