Natural killer T cell activation increases iNOS+CD206- M1 macrophage and controls the growth of solid tumor

Natural killer T cell activation increases iNOS+CD206- M1 macrophage and controls the growth of solid tumor

Abstract Background NKT cells play an important role in anti-tumor immunity. Alpha-galactosylceramide (α-GalCer), a synthetic glycolipid is presented to natural killer T (NKT) cells by most antigen-presenting cells through CD1d molecules leading to activation of NKT cells. However, the precise mecha...

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Bibliographic Details
Main Authors: Sourav Paul, Sushanta Chhatar, Amrita Mishra, Girdhari Lal
Format: Article
Language:English
Published: BMJ Publishing Group 2019-08-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Tumor microenvironment
Macrophage polarization
Th1
Natural killer T cells
CD1d
Melanoma
Online Access:http://link.springer.com/article/10.1186/s40425-019-0697-7

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http://link.springer.com/article/10.1186/s40425-019-0697-7

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