How Often Do Protein Genes Navigate Valleys of Low Fitness?

To escape from local fitness peaks, a population must navigate across valleys of low fitness. How these transitions occur, and what role they play in adaptation, have been subjects of active interest in evolutionary genetics for almost a century. However, to our knowledge, this problem has never bee...

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Bibliographic Details
Main Authors: Erik D. Nelson, Nick V. Grishin
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/10/4/283