Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA

Abstract Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models. However, continuous exposure to NAMPT inhibitors, such as FK866, can induce acquired resistance. Method...

Full description

Bibliographic Details
Main Authors: Natthakan Thongon, Chiara Zucal, Vito Giuseppe D’Agostino, Toma Tebaldi, Silvia Ravera, Federica Zamporlini, Francesco Piacente, Ruxanda Moschoi, Nadia Raffaelli, Alessandro Quattrone, Alessio Nencioni, Jean-Francois Peyron, Alessandro Provenzani
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Cancer & Metabolism
Subjects:
NAMPT
Amino acid metabolism
Drug resistance
LDHA
QPRT
Online Access:http://link.springer.com/article/10.1186/s40170-018-0174-7

Internet

http://link.springer.com/article/10.1186/s40170-018-0174-7

Similar Items