The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.

The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis.

Proteolytic tissue degradation is a typical phenomenon in inflammatory periodontal diseases. HtrA1 (High temperature requirement A 1) has a serine protease activity and is able to degrade fibronectin whose fragments induce the expression and secretion of several matrix metalloproteinases (MMPs). The...

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Bibliographic Details
Main Authors: Teresa Lorenzi, Elena Annabel Niţulescu, Antonio Zizzi, Maria Lorenzi, Francesca Paolinelli, Simone Domenico Aspriello, Monica Baniţă, Stefania Crăiţoiu, Gaia Goteri, Giorgio Barbatelli, Tommaso Lombardi, Roberto Di Felice, Daniela Marzioni, Corrado Rubini, Mario Castellucci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4076180?pdf=render

Internet

http://europepmc.org/articles/PMC4076180?pdf=render

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