Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation

Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation

Repositioning of approved drugs for identifying new therapeutic purposes is an alternative, time and cost saving strategy to classical drug development. Here, we screened a library of 786 FDA-approved drugs to find compounds, which can potentially be repurposed for treatment of T cell-mediated autoi...

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Bibliographic Details
Main Authors: Linda Voss, Karina Guttek, Annika Reddig, Annegret Reinhold, Martin Voss, Burkhart Schraven, Dirk Reinhold
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
apoptosis
DNA damage
inhibitor of T cell activation
adefovir dipivoxil
drug repositioning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.616570/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.616570/full

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