CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under hypoxia. We show that CAIX is strongly expressed i...

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Bibliographic Details
Main Authors: Astrid Drenckhan, Morton Freytag, Claudiu T. Supuran, Guido Sauter, Jakob R. Izbicki, Stephanie J. Gros
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Esophageal carcinoma
hypoxia
carbonic anhydrase IX
tumour microenvironment
targeted therapy
Online Access:http://dx.doi.org/10.1080/14756366.2018.1475369

Internet

http://dx.doi.org/10.1080/14756366.2018.1475369

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