Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles

Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles

<p>Abstract</p> <p>Background</p> <p>Gene transfer using non-viral vectors offers a non-immunogenic and safe method of gene delivery. Cellular uptake and intracellular trafficking of the nanoparticles can impact on the transfection efficiency of these vectors. Therefore...

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Bibliographic Details
Main Authors: Singh Jagbir, Michel Deborah, Chitanda Jackson M, Verrall Ronald E, Badea Ildiko
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Journal of Nanobiotechnology
Subjects:
cellular uptake
endosomal escape
non-viral gene delivery
clathrin-mediated endocytosis
caveolae-mediated endocytosis
Online Access:http://www.jnanobiotechnology.com/content/10/1/7

Internet

http://www.jnanobiotechnology.com/content/10/1/7

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