The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

Abstract Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2 Akita xVEGF +/−), which demonstrates hyperglycemia, vascular hyperpermeability...

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Bibliographic Details
Main Authors: Shyam S. Chaurasia, Rayne R. Lim, Bhav H. Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D. Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R. Mohan, Veluchamy A. Barathi
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-21198-z

Internet

https://doi.org/10.1038/s41598-018-21198-z

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