Hemoglobin promotes Aβ oligomer formation and localizes in neurons and amyloid deposits
The objective of this study was to search for brain-specific binding proteins that participated in Aβ aggregation. Immunoprecipitation of Aβ in Alzheimer's brain homogenate revealed a major co-precipitating 16-kDa protein band, which was identified through mass spectrometry as hemoglobin (Hb) α...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-12-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104001925 |