DNA Methylation Signatures and the Contribution of Age-Associated Methylomic Drift to Carcinogenesis in Early-Onset Colorectal Cancer

DNA Methylation Signatures and the Contribution of Age-Associated Methylomic Drift to Carcinogenesis in Early-Onset Colorectal Cancer

We investigated aberrant DNA methylation (DNAm) changes and the contribution of ageing-associated methylomic drift and age acceleration to early-onset colorectal cancer (EOCRC) carcinogenesis. Genome-wide DNAm profiling using the Infinium HM450K on 97 EOCRC tumour and 54 normal colonic mucosa sample...

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Bibliographic Details
Main Authors: Jihoon E. Joo, Mark Clendenning, Ee Ming Wong, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Ingrid M. Winship, Susan G. Preston, Aung Ko Win, Pierre-Antoine Dugué, Harindra Jayasekara, Dallas English, Finlay A. Macrae, John L. Hopper, Mark A. Jenkins, Roger L. Milne, Graham G. Giles, Melissa C. Southey, Daniel D. Buchanan
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
early onset colorectal cancer
colorectal cancer
DNA methylation
age acceleration
epigenetic drift
Online Access:https://www.mdpi.com/2072-6694/13/11/2589

Internet

https://www.mdpi.com/2072-6694/13/11/2589

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