Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling

Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling

Interleukin-27 (IL-27), a heterodimeric cytokine, plays a protective role in diabetes. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate food intake. The relationship between IL-27 and ghrelin is still unexplored. Here we investigated that signal transdu...

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Bibliographic Details
Main Authors: Heng Zhang, Qingjie Li, Yuxin Teng, Yubi Lin, Shaojian Li, Tingfeng Qin, Linxi Chen, Jiana Huang, Hening Zhai, Quan Yu, Geyang Xu
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
IL-27
Ghrelin
STAT3
mTOR
Food intake
Online Access:http://www.sciencedirect.com/science/article/pii/S221138351931055X

Internet

http://www.sciencedirect.com/science/article/pii/S221138351931055X

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