The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells

The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells

The chromodomain helicase DNA-binding 4 (CHD4), a member of the nucleosome remodeling and deacetylases (NuRD) complex, has been identified as an oncogene that modulates proliferation and migration of breast cancers (BC). ERBB2 is an oncogenic driver in 20–30% of BC in which its overexpression leads...

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Bibliographic Details
Main Authors: Carolina D'Alesio, Grazia Bellese, Maria Cristina Gagliani, Anastasia Lechiara, Martina Dameri, Elena Grasselli, Luisa Lanfrancone, Katia Cortese, Patrizio Castagnola
Format: Article
Language:English
Published: The Company of Biologists 2019-04-01
Series:Biology Open
Subjects:
Breast cancer
ERBB2
CHD4
Trastuzumab
Autophagy
Online Access:http://bio.biologists.org/content/8/4/bio038323

Internet

http://bio.biologists.org/content/8/4/bio038323

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