Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.

Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.

Sepsis, a major cause of morbidity/mortality in intensive care units worldwide, is commonly associated with cardiac dysfunction, which worsens the prognosis dramatically for patients. Although in recent years the concept of septic cardiomyopathy has evolved, the importance of myocardial structural a...

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Bibliographic Details
Main Authors: Mara R N Celes, Lygia M Malvestio, Sylvia O Suadicani, Cibele M Prado, Maria J Figueiredo, Erica C Campos, Ana C S Freitas, David C Spray, Herbert B Tanowitz, João S da Silva, Marcos A Rossi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720843?pdf=render

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http://europepmc.org/articles/PMC3720843?pdf=render

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