Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes

Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes

This study investigated whether treatment of articular cartilage chondrocytes with a combination of oncostatin M (OSM) and interleukin-1 (IL-1) could induce a degradative phenotype that was mediated through the protein kinase R (PKR) signalling pathway. High-density monolayer cultures of full depth,...

Full description

Bibliographic Details
Main Authors: SJ Gilbert, EJ Blain, A Al-Sabah, Y Zhang, VC Duance, DJ Mason
Format: Article
Language:English
Published: AO Research Institute Davos 2012-01-01
Series:European Cells & Materials
Subjects:
Articular cartilage
chondrocytes
protein kinase R
oncostatin M
interleukin-1
matrix metalloproteinase
aggrecanase
tumour necrosis factor alpha
type II collagen
Online Access:http://www.ecmjournal.org/journal/papers/vol023/pdf/v023a04.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol023/pdf/v023a04.pdf

Similar Items