Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice

Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice

West Nile virus (WNV) is an enveloped positive-stranded RNA virus that causes meningitis, encephalitis, and acute flaccid paralysis in humans. There are no therapeutic agents available for use against WNV infection. Alpha-2 macroglobulin (A2M) is a major plasma proteinase inhibitor that also has imp...

Full description

Bibliographic Details
Main Authors: Keeton Krause, Francine Azouz, Eileen Nakano, Vivek R. Nerurkar, Mukesh Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
West Nile virus
flavivirus
alpha-macroglobulins
pregnancy zone protein
murinoglobulin-1
neuroinflammation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00259/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00259/full

Similar Items