Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study.

Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study.

T cell directed HIV vaccines are based upon the induction of CD8+ T cell memory responses that would be effective in inhibiting infection and subsequent replication of an infecting HIV-1 strain, a process that requires a match or near-match between the epitope induced by vaccination and the infectin...

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Bibliographic Details
Main Authors: Fusheng Li, Adam C Finnefrock, Sheri A Dubey, Bette T M Korber, James Szinger, Suzanne Cole, M Juliana McElrath, John W Shiver, Danilo R Casimiro, Lawrence Corey, Steven G Self
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3112144?pdf=render

Internet

http://europepmc.org/articles/PMC3112144?pdf=render

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