Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Abstract Background Endoplasmic reticulum (ER) stress and its consequent unfolded protein response (UPR) are believed to be associated with progression, survival and chemoresistance of a variety of tumor cells through multiple cellular processes, including autophagy. Therefore, the ER stress-autopha...

Full description

Bibliographic Details
Main Authors: Prakash C. Thakur, Jennifer L. Miller-Ocuin, Khanh Nguyen, Rina Matsuda, Aatur D. Singhi, Herbert J. Zeh, Nathan Bahary
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Translational Medicine
Subjects:
PDAC
ER stress
UPR
Autophagy
Pancreatic cancer
Online Access:http://link.springer.com/article/10.1186/s12967-018-1562-z

Internet

http://link.springer.com/article/10.1186/s12967-018-1562-z

Similar Items