Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility

Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility

Purpose: Hyperpolarization-activated cyclic nucleotide gated non-selective (HCN) channels have been demonstrated in the urinary bladder in various species. Since they play a major role in governing rhythmic activity in pacemaker cells like in the sinoatrial node, we explored the role of these channe...

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Bibliographic Details
Main Authors: Felix Mader, Steffen Müller, Ludwig Krause, Armin Springer, Karoline Kernig, Chris Protzel, Katrin Porath, Simone Rackow, Tristan Wittstock, Marcus Frank, Oliver W. Hakenberg, Rüdiger Köhling, Timo Kirschstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
ZD7288
18β-glycyrrhetic acid
HCN1 knockout
electron microscopy
organ bath
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00753/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00753/full

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